MECHANISMS OF SEIZURES

• The precis mehanism is unknown.
• Several physiological facotrs.
• Group of neurons generating signigicant bust dicharge.
• impairment of GABAergic inhibitory Systerm.
• Excitatory Glutamatergic synapses & Amino -acids.
• Areas of neuronald death,reorgainzation after injury.
• Kindling.
• Age Specific -- ? undederdeve loped brain.
• Functional immaturinty of substantia nigra.
• Genetic Factors