IVIG IN PEDIATRICS

INTRODUCTION



Intravenous immunoglobulin (IVIG) are sterile, purified immunoglobulin G (IgG) products manufacture from pooled human plasma from several thousand healthy donors and typically contain more than 95% unmodified IgG , and only trace amounts of IgA or IgM.
IVIG preparations will contain the entire spectrum of antibodies that are present in normal human serum.


STRUCTURE OF IMMUNOGLOBULIN

1.Immunoglobulins are glycoprotiens
2.Each molecule consisting of two pairs of polypeptide chains of different sizes.
3.Smaller chains – light chains
4.Larger chains – heavy chains